Serum Substitutes
Cayman Chemical SR 142948hydrochlorIde 10mg
A neurotensin receptor antagonist (IC50s = 1.19, 0.32, and 3.96 nM for human recombinant NTS receptors expressed in CHO cells, HT-29 cells, and adult rat brain membranes, respectively); inhibits inositol phosphate formation in HT-29 cells (IC50 = 3.9 nM); inhibits the firing rate of rat ventral pallidum neurons (1 mg/kg, i.v.); inhibits neurotensin-induced turning behavior in mice (40-640 mg/kg) as well as other neurotensin-induced cellular and behavioral responses
Biolegend Spark UVTM 387 anti-mouse IFN-
Spark UV™ 387 anti-mouse IFN-γ [XMG1.2]; Isotype: Rat IgG1, κ; Reactivity: Mouse; Apps: ICFC; Size: 100 μg
Cayman Chemical SR 59230AhydrochlorIde 5mg
A β3-AR antagonist in animal models; less selective for human β-AR subtypes (Kis = 16.4, 61.9, and 122 nM for β1-, β2-, and β3-AR, respectively); blocks MDMA-induced hyperthermia at low and high concentrations with some α1-AR antagonist properties
Cayman Chemical SR 58611AhydrochlorIde 10mg
A selective β3-AR agonist (EC50 = 3.5 nM in rat colon); minimally active against β1-ARs in rat uterus (EC50 = 499 nM) and inactive against β2-ARs in guinea pig trachea and atrium (EC50s = >10,000 and >30,000 nM, respectively); activates brown fat metabolism through activation of adenylyl cyclase activity and glycerol release in brown adipocytes (EC50s = 20 and 11 nM, respectively); reduces hypothermia produced by apomorphine and reserpine; potentiates toxicity produced by yohimbine; reduces number of escape failures in a learned helplessness model of antidepressant-like activity in rats
Biolegend Brilliant Violet 650TM anti-hu
Brilliant Violet 650™ anti-human IFN-γ [B27]; Isotype: Mouse IgG1, κ; Reactivity: Human; Apps: ICFC; Size: 25 tests
Abcam Human RIPK2 (RIP2) knockout HeLa cell line
Human RIPK2 (RIP2) knockout HeLa cell line
The product is subject to the following: Abcam Restricted Use Statement
![Biolegend APC/Fire™ 750 anti-mouse IFN-γ [W18272D]; Isotype: Rat IgG2b, κ; Reactivity: Mouse; Apps: ICFC; Size: 25 μg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/502567352.png-250.jpg)
Biolegend APC/Fire™ 750 anti-mouse IFN-γ [W18272D]; Isotype: Rat IgG2b, κ; Reactivity: Mouse; Apps: ICFC; Size: 25 μg
APC/Fire™ 750 anti-mouse IFN-γ [W18272D]; Isotype: Rat IgG2b, κ; Reactivity: Mouse; Apps: ICFC; Size: 25 μg
Cayman Chemical SR 717lIthIum salt 5mg
A STING agonist (EC50 = 2.1 µM in a reporter assay); selective for STING over a panel of 468 kinases; increases plasma IFN-β and IL-6 levels in mice at 30 mg/kg; increases the intratumor frequency of CD69+CD8+ T cells, reduces tumor growth, and increases survival in a B16/F10 murine melanoma model
Cayman Chemical SR 57227AhydrochlorIde 10mg
A 5-HT3 receptor agonist; selectively binds 5-HT3 receptors (IC50 = 2.8 nM) over 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2, and 5-HT4 receptors (IC50s = >1,000 nM for all); induces contractions in isolated guinea pig ileum at 20 µM; intrastriatal administration induces contralateral turning behavior in mice at 1 UG/animal; reduces immobility time in the forced swim test in rats (ED50 = 7.6 mg/kg); reduces the number of escape failures in a rat model of learned helplessness and the duration of fighting in a mouse model of isolation-induced aggression
Cayman Chemical SR 57227AhydrochlorIde 50mg
A 5-HT3 receptor agonist; selectively binds 5-HT3 receptors (IC50 = 2.8 nM) over 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2, and 5-HT4 receptors (IC50s = >1,000 nM for all); induces contractions in isolated guinea pig ileum at 20 µM; intrastriatal administration induces contralateral turning behavior in mice at 1 UG/animal; reduces immobility time in the forced swim test in rats (ED50 = 7.6 mg/kg); reduces the number of escape failures in a rat model of learned helplessness and the duration of fighting in a mouse model of isolation-induced aggression
Cayman Chemical SR 1555hydrochlorIde 10mg
A selective ligand of RORγ (IC50 = 1 μM); does not bind RORα, LXR, or FXR; acts as an inverse agonist of RORγ, inhibiting endogenous IL-17A gene expression and suppressing differentiation of TH17 cells; stimulates T regulatory development