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A selective ligand of RORγ (IC50 = 1 μM); does not bind RORα, LXR, or FXR; acts as an inverse agonist of RORγ, inhibiting endogenous IL-17A gene expression and suppressing differentiation of TH17 cells; stimulates T regulatory development
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The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2 and facilitates cell entry by the virus, SARS-CoV2.
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A derivative of GABA that acts as an antagonist of GABAA receptors (Ki = 74-150 nM); elicits seizures when administered intravenously in mice; effective against GABAA receptor isoforms from mice, rats, and humans
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
A derivative of GABA that acts as an antagonist of GABAA receptors (Ki = 74-150 nM); elicits seizures when administered intravenously in mice; effective against GABAA receptor isoforms from mice, rats, and humans
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
A derivative of GABA that acts as an antagonist of GABAA receptors (Ki = 74-150 nM); elicits seizures when administered intravenously in mice; effective against GABAA receptor isoforms from mice, rats, and humans
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
A STING agonist (EC50 = 2.1 µM in a reporter assay); selective for STING over a panel of 468 kinases; increases plasma IFN-β and IL-6 levels in mice at 30 mg/kg; increases the intratumor frequency of CD69+CD8+ T cells, reduces tumor growth, and increases survival in a B16/F10 murine melanoma model
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More
A STING agonist (EC50 = 2.1 µM in a reporter assay); selective for STING over a panel of 468 kinases; increases plasma IFN-β and IL-6 levels in mice at 30 mg/kg; increases the intratumor frequency of CD69+CD8+ T cells, reduces tumor growth, and increases survival in a B16/F10 murine melanoma model
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More